Sodium borohydride → HCID 18334248, compound

HRID 2269472Notes

Reaction equation

HRID 2269472 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:11][CH:12]([C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-])=O)[CH:14]=2)[CH3:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:11][CH:12]([C:22]2[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=2)[C:13]2[CH:14]=[C:15]([NH2:19])[CH:16]=[CH:17][CH:18]=2)[CH3:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 18334143HCID 18334143, compound

Product 1

HCID 18334248HCID 18334248, compound

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following, a similar reaction, separation and purification procedure to that described in Example (59b), 3.39 g of N-[1-(3,5-dichlorophenyl)ethyl]-N-[(4-fluorophenyl)-(3-nitrophenyl)methyl]amine [prepared as described in step (a) above], 3.86 g of nickel chloride hexahydrate and 1.23 g of sodium borohydride were reacted, to obtain 970 mg of isomer A and 567 mg of isomer B of the title compound as a pale yellow oil and a white solid, respectively.

Workup

  1. customa similar reaction, separation and purification procedure to
  2. customwere reacted

Sources & evidence

ORD record
ord-d9b50d97596049acb4a9b6192b6b35f9
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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