Sodium borohydride → HCID 18347071, compound

HRID 2269476Notes

Reaction equation

HRID 2269476 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:11][CH:12]([C:26]2[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=2)[C:13]2[CH:18]=[C:17]([N+:19]([O-])=O)[C:16]([O:22][CH3:23])=[C:15]([O:24][CH3:25])[CH:14]=2)[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8].[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:11][CH:12]([C:26]2[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=2)[C:13]2[CH:14]=[C:15]([O:24][CH3:25])[C:16]([O:22][CH3:23])=[C:17]([NH2:19])[CH:18]=2)[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 18334113HCID 18334113, compound

Product 1

HCID 18347071HCID 18347071, compound

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following a similar reaction, separation and purification procedure to that described in Example (59b), 3.42 g of N-[1-(3,4-difluorophenyl)ethyl]-N-[(4-fluorophenyl)-(3,4-dimethoxy-5-nitrophenyl)methyl]amine [prepared as described in step (a) above], 3.65 g of nickel chloride hexahydrate and 1.17 g of sodium borohydride were reacted, to obtain 1.10 g of isomer A and 1.39 g of isomer B of the title compound as pale yellow oils, respectively.

Workup

  1. customa similar reaction, separation and purification procedure to
  2. customwere reacted

Sources & evidence

ORD record
ord-103e2c133a9e4174820c73e9c4ddff82
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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