4-Fluoro-3'-nitrobenzophenone → N-[(R)-1-(3,4-Difluorophenyl)ethyl]-N-[(4-fluorophenyl)-(3-nitrophenyl)methyl]amine

HRID 2269479Notes

Reaction equation

HRID 2269479 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)=O)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].Cl.[F:20][C:21]1[CH:22]=[C:23]([C@H:28]([NH2:30])[CH3:29])[CH:24]=[CH:25][C:26]=1[F:27]>>[F:20][C:21]1[CH:22]=[C:23]([C@H:28]([NH:30][CH:10]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[C:6]2[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)[CH3:29])[CH:24]=[CH:25][C:26]=1[F:27]

Participants

3

Reactant 2

HCID 104905584-Fluoro-3'-nitrobenzophenoneHCID 45072357(R)-1-(3,4-Difluorophenyl)ethanamine hydrochloride

Product 1

HCID 70189099N-[(R)-1-(3,4-Difluorophenyl)ethyl]-N-[(4-fluorophenyl)-(3-nitrophenyl)methyl]amineYield 90.8%

Procedure

Following a similar procedure to that described in Example (1a), 12.91 g of 4-fluorophenyl 3-nitrophenyl ketone and 10.19 g of (R)-1-(3,4-difluorophenyl)ethylamine hydrochloride were reacted, to obtain 18.47 g of the title compound as a pale yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-e7ec54905cf24213aabf881625946690
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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