HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-3'-nitrobenzophenone → N-[(R)-1-(3,4-Difluorophenyl)ethyl]-N-[(4-fluorophenyl)-(3-nitrophenyl)methyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-3'-nitrobenzophenone | HCID 10490558 | — |
| Reactant | (R)-1-(3,4-Difluorophenyl)ethanamine hydrochloride | HCID 45072357 | — |
| Product | N-[(R)-1-(3,4-Difluorophenyl)ethyl]-N-[(4-fluorophenyl)-(3-nitrophenyl)methyl]amine | HCID 70189099 | 90.8% |
Reaction Steps
Following a similar procedure to that described in Example (1a), 12.91 g of 4-fluorophenyl 3-nitrophenyl ketone and 10.19 g of (R)-1-(3,4-difluorophenyl)ethylamine hydrochloride were reacted, to obtain 18.47 g of the title compound as a pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-e7ec54905cf24213aabf881625946690 |
| Source note | uspto-grants-2001_12 |