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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2269483Generated: November 1, 2026

Sodium → HCID 70189793, compound

https://huagongshe.com/reaction/2269483

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodiumHCID 5360545—
ReactantHCID 70188096HCID 70188096—
CatalystDichloronickel;hexahydrateHCID 11791229—
SolventMethanolHCID 887—
ProductHCID 70189793HCID 70189793—

Reaction Steps

Following a similar procedure to that described in Example (1b), 2.82 g of isomer A of N-[(R)-1-(3-fluorophenyl)ethyl]-N-[(4-fluorophenyl)-(3-nitrophenyl)methyl]amine [prepared as described in step (a) above], 3.64 g of nickel chloride hexahydrate, 1.16 g of sodium borolydride and 30 ml of methanol were reacted, to obtain 2.52 g of isomer A of the title compound as a colorless oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06329405B1
Source datasetuspto-grants-2001_12
ORD IDord-059e4104b9ac47feb543307836708918
Source noteuspto-grants-2001_12