Sodium → HCID 70189793, compound

HRID 2269483Notes

Reaction equation

HRID 2269483 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C@H:8]([NH:10][CH:11]([C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-])=O)[CH:13]=2)[CH3:9])[CH:5]=[CH:6][CH:7]=1.[Na]>O.O.O.O.O.O.[Ni](Cl)Cl.CO>[F:27][C:24]1[CH:25]=[CH:26][C:21]([CH:11]([NH:10][C@@H:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=2)[CH3:9])[C:12]2[CH:13]=[C:14]([NH2:18])[CH:15]=[CH:16][CH:17]=2)=[CH:22][CH:23]=1

Participants

5

Reactant 2

HCID 5360545SodiumHCID 70188096HCID 70188096, compound

Product 1

HCID 70189793HCID 70189793, compound

Reagents, catalysts & solvents 2

HCID 11791229Dichloronickel;hexahydrateCatalystHCID 887MethanolSolvent

Procedure

Following a similar procedure to that described in Example (1b), 2.82 g of isomer A of N-[(R)-1-(3-fluorophenyl)ethyl]-N-[(4-fluorophenyl)-(3-nitrophenyl)methyl]amine [prepared as described in step (a) above], 3.64 g of nickel chloride hexahydrate, 1.16 g of sodium borolydride and 30 ml of methanol were reacted, to obtain 2.52 g of isomer A of the title compound as a colorless oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-059e4104b9ac47feb543307836708918
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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