Sodium borohydride → HCID 70189348, compound

HRID 2269486Notes

Reaction equation

HRID 2269486 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:11][CH:12]([C:22]2[CH:27]=[CH:26][C:25]([S:28][CH3:29])=[CH:24][CH:23]=2)[C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-])=O)[CH:14]=2)[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8].[BH4-].[Na+]>[Ni](Cl)Cl.CO>[F:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:11][CH:12]([C:22]2[CH:23]=[CH:24][C:25]([S:28][CH3:29])=[CH:26][CH:27]=2)[C:13]2[CH:14]=[C:15]([NH2:19])[CH:16]=[CH:17][CH:18]=2)[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 70189130HCID 70189130, compound

Product 1

HCID 70189348HCID 70189348, compound

Reagents, catalysts & solvents 2

HCID 24385Nickel DichlorideCatalystHCID 887MethanolSolvent

Procedure

Following a similar reaction, separation and purification procedure to that described in Example (59b), 3.74 g of N-[1-(3,4-difluorophenyl)ethyl]-N-[(4-methylthiophenyl)-(3-nitrophenyl)methyl]amine [prepared as described in step (a) above], 4.29 g of nickel chloride lhexahydrate, 1.37 g of sodium borohydride and 80 ml of methanol were reacted, to obtain 796 mg of isomer A and 400 mg of isomer B of the title compound as colorless oils, respectively.

Workup

  1. customa similar reaction, separation and purification procedure to
  2. customwere reacted

Sources & evidence

ORD record
ord-2f43310c815642149595f7e270f45e11
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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