Sodium borohydride → HCID 18334152, compound

HRID 2269488Notes

Reaction equation

HRID 2269488 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:11][CH:12]([C:22]2[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][C:23]=2[O:30][CH3:31])[C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-])=O)[CH:14]=2)[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8].[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl.CO>[F:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:11][CH:12]([C:22]2[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][C:23]=2[O:30][CH3:31])[C:13]2[CH:14]=[C:15]([NH2:19])[CH:16]=[CH:17][CH:18]=2)[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 18334205HCID 18334205, compound

Product 1

HCID 18334152HCID 18334152, compound

Reagents, catalysts & solvents 2

HCID 11791229Dichloronickel;hexahydrateCatalystHCID 887MethanolSolvent

Procedure

Following a similar procedure to that described in Example (1b), 720 mg of isorner B of N-[1-(3,4-difluorophenyl)ethyl]-N-[(2,4-dimethoxyphenyl)-(3-nitrophenyl)methyl]amine [prepared as described in step (a) above], 799 mg of nickel chloride hexahydrate, 254 mg of sodium borohydride and 80 ml of methanol were reacted, to obtain 580 mg of isomer B of the title compound as a colorless oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-fb3e60a45a0840af9a099701de17c868
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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