Sodium borohydride → HCID 70189115, compound

HRID 2269498Notes

Reaction equation

HRID 2269498 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([N+:26]([O-])=O)[CH:21]=2)[NH:10][C:11]([CH3:19])([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH3:12])=[CH:5][CH:4]=1.[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl.CO>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]([NH:10][C:11]([CH3:19])([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH3:12])[C:20]2[CH:21]=[C:22]([NH2:26])[CH:23]=[CH:24][CH:25]=2)=[CH:7][CH:8]=1

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 18334081HCID 18334081, compound

Product 1

HCID 70189115HCID 70189115, compoundYield 94.6%

Reagents, catalysts & solvents 2

HCID 11791229Dichloronickel;hexahydrateCatalystHCID 887MethanolSolvent

Procedure

Following a similar procedure to that described in Example (94b), 1.39 g of N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]-N-(1-methyl-1-phenylethyl)amine [prepared as described in step (a) above], 1.76 g of nickel chloride hexahydrate, 559 mg of sodium borohydride and 100 ml of methanol were reacted, to obtain 1.21 g of the title compound as a yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-758f9eb6510b4fc5866ea9103a1ee204
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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