Sodium borohydride → HCID 18347023, compound

HRID 2269501Notes

Reaction equation

HRID 2269501 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([N+:27]([O-])=O)[CH:22]=2)[NH:9][CH:10]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[C:14]([F:19])[C:13]=2[F:20])[CH3:11])=[CH:4][CH:3]=1.[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:9][CH:10]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[C:14]([F:19])[C:13]=2[F:20])[CH3:11])[C:21]2[CH:22]=[C:23]([NH2:27])[CH:24]=[CH:25][CH:26]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 18334215HCID 18334215, compound

Product 1

HCID 18347023HCID 18347023, compound

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following a similar reaction, separation and purification procedure to that described in Example (59b), 3.96 g of N-[(4-chlorophenyl)-(3-nitrophenyl)methyl]-N-[1-(2,3,4-trifluorophenyl)ethyl]amine [prepared as described in step (a) above], 4.47 g of nickel chloride hexahydrate and 1.42g of sodium borohydride were reacted, to obtain 1.05 g of isomer A and 720 mg, of isomer B of the title compound, each as a pale yellow oil.

Workup

  1. customa similar reaction, separation and purification procedure to
  2. customwere reacted
  3. customto obtain 1.05 g of isomer A and 720 mg

Sources & evidence

ORD record
ord-432887d57e89415fb2f04f072d38970e
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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