Sodium borohydride → HCID 70188092, compound

HRID 2269502Notes

Reaction equation

HRID 2269502 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([NH:10][CH:11]([C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-])=O)[CH:13]=2)[CH3:9])=[CH:4][CH:3]=1.[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([NH:10][CH:11]([C:21]2[CH:22]=[CH:23][C:24]([O:27][CH3:28])=[CH:25][CH:26]=2)[C:12]2[CH:13]=[C:14]([NH2:18])[CH:15]=[CH:16][CH:17]=2)[CH3:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 70189279HCID 70189279, compound

Product 1

HCID 70188092HCID 70188092, compound

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following a similar reaction, separation and purification procedure to that described in Example (59b), 7.60 g of N-[(R)-1-(4-fluorophenyl)ethyl]-N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]amine [prepared as described in step (a) above], 9.51 g of nickel chloride hexahydrate and 3.03 g of sodium borohydride were reacted, to obtain 1.52 g of isomer A and 1.39 g of isomer B of the title compound, each as a pale yellow oil.

Workup

  1. customa similar reaction, separation and purification procedure to
  2. customwere reacted

Sources & evidence

ORD record
ord-d29cc765119948d78d1cb58d4a4213f0
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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