Sodium borohydride → HCID 70188151, compound

HRID 2269503Notes

Reaction equation

HRID 2269503 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C@H:9]([NH:11][CH:12]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([N+:26]([O-])=O)[CH:21]=2)[C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8].[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([C@H:9]([NH:11][CH:12]([C:13]2[CH:14]=[CH:15][C:16]([CH3:19])=[CH:17][CH:18]=2)[C:20]2[CH:21]=[C:22]([NH2:26])[CH:23]=[CH:24][CH:25]=2)[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 20712484HCID 20712484, compound

Product 1

HCID 70188151HCID 70188151, compound

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following a similar reaction, separation and purification procedure to that described in Example (59b), 5.88 g of N-[(R)-1-(3 4-difluorophenyl)ethyl]-N-[(3-nitrophenyl)-(p-tolyl)methyl]amine [prepared as described in step (a) above], 7.31 g of nickel chloride hexahydrate and 2.33 g of sodium borohydride were reacted, to obtain 0.91 g of isomer A and 335 mg of isomer B of the title compound, each as a colorless oil.

Workup

  1. customa similar reaction, separation and purification procedure to
  2. customwere reacted

Sources & evidence

ORD record
ord-979723bf99144255bea9c381fc7341f7
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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