Sodium borohydride → HCID 70190185, compound

HRID 2269504Notes

Reaction equation

HRID 2269504 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([N+:28]([O-])=O)[CH:23]=2)[NH:10][C@@H:11]([C:13]2[CH:18]=[C:17]([F:19])[C:16]([F:20])=[C:15]([F:21])[CH:14]=2)[CH3:12])=[CH:5][CH:4]=1.[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([NH:10][C@@H:11]([C:13]2[CH:14]=[C:15]([F:21])[C:16]([F:20])=[C:17]([F:19])[CH:18]=2)[CH3:12])[C:22]2[CH:23]=[C:24]([NH2:28])[CH:25]=[CH:26][CH:27]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 70188095HCID 70188095, compound

Product 1

HCID 70190185HCID 70190185, compoundYield 96.2%

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following a similar procedure to that described in Example (1b), 2.61 g of N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]-N-[(R)-1-(3,4,5-trifluorophenyl)ethyl]amine [prepared as described in step (a) above], 3.00 g of nickel chloride hexahydrate and 958 mg of sodium borohydride were reacted, to obtain 2.33 g of the title compound as a colorless oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-df4a2775aca44c31a1df5dbc881a993d
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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