Sodium borohydride → HCID 70189220, compound

HRID 2269507Notes

Reaction equation

HRID 2269507 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C@H:9]([NH:11][CH:12]([C:22]2[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][CH:23]=2)[C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-])=O)[CH:14]=2)[CH3:10])[CH:5]=[C:6]([F:8])[CH:7]=1.[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([C@H:9]([NH:11][CH:12]([C:22]2[CH:23]=[CH:24][C:25]([CH3:28])=[CH:26][CH:27]=2)[C:13]2[CH:14]=[C:15]([NH2:19])[CH:16]=[CH:17][CH:18]=2)[CH3:10])[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 20712485N-[(R)-1-(3,5-difluorophenyl)ethyl]-N-[(4-methylphenyl)-(3-nitrophenyl)methyl]amine

Product 1

HCID 70189220HCID 70189220, compound

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following a similar reaction, separation and purification procedure to that described in Example (59b), 2.59 g of N -[(R)-1-(3,5-difluorophenyl)ethyl]-N-[(4-methylphenyl)-(3-nitrophenyl)methyl]amine [prepared as described in step (a) above], 3.23 g of nickel chloride hexahydrate and 1.03 g of sodium borohydride were reacted, to obtain 1.02 g of isomer A and 1.08 g of isomer B of the title compound, each as a colorless oil.

Workup

  1. customa similar reaction, separation and purification procedure to
  2. customwere reacted

Sources & evidence

ORD record
ord-e4c108a023c64d3db6f81e29e9da5653
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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