HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → HCID 70189220, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | N-[(R)-1-(3,5-difluorophenyl)ethyl]-N-[(4-methylphenyl)-(3-nitrophenyl)methyl]amine | HCID 20712485 | — |
| Catalyst | Dichloronickel;hexahydrate | HCID 11791229 | — |
| Product | HCID 70189220 | HCID 70189220 | — |
Reaction Steps
Following a similar reaction, separation and purification procedure to that described in Example (59b), 2.59 g of N -[(R)-1-(3,5-difluorophenyl)ethyl]-N-[(4-methylphenyl)-(3-nitrophenyl)methyl]amine [prepared as described in step (a) above], 3.23 g of nickel chloride hexahydrate and 1.03 g of sodium borohydride were reacted, to obtain 1.02 g of isomer A and 1.08 g of isomer B of the title compound, each as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-e4c108a023c64d3db6f81e29e9da5653 |
| Source note | uspto-grants-2001_12 |