Sodium borohydride → HCID 70189105, compound

HRID 2269510Notes

Reaction equation

HRID 2269510 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([N+:29]([O-])=O)[CH:24]=2)[NH:10][C@@H:11]([C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=2)[CH3:12])=[CH:5][CH:4]=1.[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([NH:10][C@@H:11]([C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=2)[CH3:12])[C:23]2[CH:24]=[C:25]([NH2:29])[CH:26]=[CH:27][CH:28]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 70189281HCID 70189281, compound

Product 1

HCID 70189105HCID 70189105, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following a similar procedure to that described in Example (1b), 6.13 g of N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]-N-[(R)-1-(naphthalen-2-yl)ethyl]amine [prepared as described in step (a) above], 7.06 g of nickel chloride hexahydrate and 2.25 g of sodium borohydride were reacted, to obtain 5.23 g of the title compound as a pale yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-d8b896350bf9480eb6efe36bb89c6096
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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