Sodium borohydride → HCID 18334079, compound

HRID 2269511Notes

Reaction equation

HRID 2269511 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:11][CH:12]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([N+:25]([O-])=O)[CH:20]=2)[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8].[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:11][CH:12]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[C:19]2[CH:20]=[C:21]([NH2:25])[CH:22]=[CH:23][CH:24]=2)[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 18347132HCID 18347132, compound

Product 1

HCID 18334079HCID 18334079, compoundYield 36%

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following a similar reaction, separation and purification procedure to that described in Example (1b). 2.07 g of N-[1-(3,4-difluorophenyl)ethyl]-N-[(3-nitrophenyl)(pyridin-4-yl)methyl]amine [prepared as described in step (a) above], 2.66 g of nickel chloride hexahydrate and 848 mg of sodium borohydride were reacted, to obtain 684 mg of the title compound as a colorless oil.

Workup

  1. customa similar reaction, separation and purification procedure to

Sources & evidence

ORD record
ord-81892935bce84d82a57a20d874c28802
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

Loading…