Sodium borohydride → HCID 70188091, compound

HRID 2269518Notes

Reaction equation

HRID 2269518 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([N+:25]([O-])=O)[CH:20]=2)[NH:10][C@@H:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH3:12])=[CH:5][CH:4]=1.[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]([NH:10][C@@H:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH3:12])[C:19]2[CH:20]=[C:21]([NH2:25])[CH:22]=[CH:23][CH:24]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 70189329HCID 70189329, compound

Product 1

HCID 70188091HCID 70188091, compound

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following a procedure similar to that described in Example (59b), 2.06 g of N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]-N-[(R)-1-phenylethyl]amine [prepared as described in step (a) above], 2.70 g of nickel chloride hexahydrate and 860 mg of sodium borohydride were reacted, separated and purified, to obtain 510 mg of isomer A and 672 mg of isomer B of the title compound, each as a yellow oil.

Workup

  1. customwere reacted
  2. customseparated
  3. custompurified

Sources & evidence

ORD record
ord-f1ef6d889b0e45269beb4e8b843b7f54
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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