Sodium borohydride → HCID 70189280, compound

HRID 2269519Notes

Reaction equation

HRID 2269519 reaction equation
[C:1]1([CH3:27])[CH:6]=[CH:5][C:4]([CH:7]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([N+:24]([O-])=O)[CH:19]=2)[NH:8][C@@H:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[CH:12]=2)[CH3:10])=[CH:3][CH:2]=1.[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[C:1]1([CH3:27])[CH:2]=[CH:3][C:4]([CH:7]([NH:8][C@@H:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[CH:12]=2)[CH3:10])[C:18]2[CH:19]=[C:20]([NH2:24])[CH:21]=[CH:22][CH:23]=2)=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 70189226HCID 70189226, compound

Product 1

HCID 70189280HCID 70189280, compound

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following a procedure similar to that described in Example (59b), 3.59 g of N-[(p-tolyl)-(3-nitrophenyl)methyl]-N-[(R)-1-(3-fluorophenyl)ethyl]amine [prepared as described in step (a) above], 4.68 g of nickel chloride hexahydrate and 1.49 g of sodium borohydride were reacted, separated and purified, to obtain 955 mg of isomer A and 649 mg of isomer B of the title compound, each as a yellow oil.

Workup

  1. customwere reacted
  2. customseparated
  3. custompurified

Sources & evidence

ORD record
ord-3278df609954476c9c2b9698c125b3e6
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

Loading…