HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 3-{Phenyl-[(R)-1-(3-fluorophenyl)ethylamino]methyl}phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | N-[(R)-1-(3-Fluorophenyl)ethyl]-N-[(3-nitrophenyl)phenylmethyl]amine | HCID 70189344 | — |
| Catalyst | Dichloronickel;hexahydrate | HCID 11791229 | — |
| Product | 3-{Phenyl-[(R)-1-(3-fluorophenyl)ethylamino]methyl}phenylamine | HCID 70188111 | 92.6% |
Reaction Steps
Following a procedure similar to that described in Example (1b), 1.37 g of N-[phenyl-(3-nitrophenyl)methyl]-N-[(R)-1-(3-fluorophenyl)ethyl)amine [prepared as described in step (a) above], 2.14 g of nickel chloride hexahydrate and 623 mg of sodium borohydride were reacted, to obtain 1.16 g of the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-3707165503f74bae86c7f01b829e8667 |
| Source note | uspto-grants-2001_12 |