Sodium borohydride → HCID 70189766, compound

HRID 2269525Notes

Reaction equation

HRID 2269525 reaction equation
[C:1]1([CH:7]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([N+:27]([O-])=O)[CH:22]=2)[NH:8][C@@H:9]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=[CH:13][CH:12]=2)[CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[C:1]1([CH:7]([NH:8][C@@H:9]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=[CH:13][CH:12]=2)[CH3:10])[C:21]2[CH:22]=[C:23]([NH2:27])[CH:24]=[CH:25][CH:26]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 70189330HCID 70189330, compound

Product 1

HCID 70189766HCID 70189766, compoundYield 93.9%

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following a procedure similar to that described in Example (1b), 1.56 g of N-[phenyl-(3-nitrophenyl)methyl]-N-[(R)-1-(napthalen-1-yl)ethyl]amine [prepared as described in step (a) above], 2.23 g of nickel chloride hexahydrate and 650 mg of sodium borohydride were reacted, to obtain 1.35 g of the title compound as a yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-b1c9432a2b3d497ba3e1301d12a2a9a2
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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