Sodium borohydride → HCID 70188141, compound

HRID 2269526Notes

Reaction equation

HRID 2269526 reaction equation
[C:1]1([CH3:30])[CH:6]=[CH:5][C:4]([CH:7]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([N+:27]([O-])=O)[CH:22]=2)[NH:8][C@@H:9]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=[CH:13][CH:12]=2)[CH3:10])=[CH:3][CH:2]=1.[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl>[C:1]1([CH3:30])[CH:6]=[CH:5][C:4]([CH:7]([NH:8][C@@H:9]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=[CH:13][CH:12]=2)[CH3:10])[C:21]2[CH:22]=[C:23]([NH2:27])[CH:24]=[CH:25][CH:26]=2)=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 70189245HCID 70189245, compound

Product 1

HCID 70188141HCID 70188141, compoundYield 100.3%

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following a procedure similar to that described in Example (1B), 1.51 g of N-[p-tolyl-(3-nitrophenyl)methyl]-N-[(R)-1-(naphthalen-1-yl)ethyl]amine [prepared as described in step (a) above], 2.08 g of nickel chloride hexahydrate and 607 mg of sodium borohydride were reacted, separated and purified, to obtain 1.40 g of the title compound as a yellow oil.

Workup

  1. customwere reacted
  2. customseparated
  3. custompurified

Sources & evidence

ORD record
ord-64c3ee231cb3403e8e84de3a4d087155
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

Loading…