Isobutylamine → HCID 28165295, compound

HRID 2269627Notes

Reaction equation

HRID 2269627 reaction equation
[NH:1]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[C@H:2]([C:6]([OH:8])=O)[CH:3]([CH3:5])[CH3:4].[CH2:16]([NH2:20])[CH:17]([CH3:19])[CH3:18].C1C=CC2N(O)N=NC=2C=1.C1CCC(N=C=NC2CCCCC2)CC1>CN(C=O)C>[NH:1]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[C@H:2]([C:6]([NH:20][CH2:16][CH:17]([CH3:19])[CH3:18])=[O:8])[CH:3]([CH3:4])[CH3:5]

Participants

6

Reactant 4

HCID 6558IsobutylamineHCID 10868DicyclohexylcarbodiimideHCID 757711-HydroxybenzotriazoleHCID 83693Boc-L-Valine

Product 1

HCID 28165295HCID 28165295, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a DMF solution containing 2.0 g of Boc-Val-OH, 0.92 ml of isobutylamine, 1.40 g of HOBt and 2.28 g of DCC were added under ice cooling and the resultant mixture was stirred for 14 hr. The reaction mixture was treated similarly to that in Example 51 (Process 1) to give 1.89 g of the title compound.

Workup

  1. additionwere added under ice cooling
  2. additionThe reaction mixture was treated similarly to that in Example 51 (Process 1)

Sources & evidence

ORD record
ord-279d5b5d74da4e9eacba2b8975382826
Source dataset
uspto-grants-2001_12
Patent number
US06329502B1

Reaction notes

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