反应详情

温度

-78 °C

A 0.5 liter, 4-necked, round-bottom flask, equipped with an overhead stirrer, thermocouple, addition funnel and a nitrogen inlet/outlet was charged with 11.4 g of lithium chloride (dried in vacuo at 130° C. for 6 hours and then at 100° C. for 18 hours prior to use), 9.1 g of diisoproylamine and 80 ml of tetrahydrofuran. After cooling to −78° C., a 2.5 M solution of n-butyllithium in hexanes (35 ml) was added over about 20 minutes while maintaining the temperature at less than or equal to −60° C. This mixture was allowed to stir at −78° C. for 45 minutes. A tetrahydrofuran solution of [R-(R*,R*)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methyl-α-aminoacetamide monohydrate [10 g., 0.04 mol, prepared as described by Myers et al., Tetrahedron Letters, Vol. 36, p. 4555-4558 (1995)] was added over 50 minutes while maintaining the temperature at less than or equal to−68° C. After the addition was complete, the mixture was stirred for an additional 45 minutes. The solution was allowed to warm to about 0° C. and held at that temperature for 45 minutes. The 2-(3-iodopropyl)-1,3-dioxolane (12g) from part (a) was added as a tetrahydrofuran (10 ml) solution in one portion. After 3 hours reaction time at 0° C., TLC analysis indicated no observable starting material present and water (100 ml) was added as a quench. The tetrahydrofuran/hexane phase was separated from the lower aqueous phase. The aqueous phase was extracted with methylene chloride (4×100 ml). The methylene chloride phases were combined with the tetrahydrofuran/hexane phase and washed with 100 ml of brine. After drying over sodium sulfate and filtration, concentration in vacuo (bath temperature less than or equal to 40° C.) afforded an oil (9.57g). The oil was chromatographed over silica gel 60 (column size: 3.5 cm×21 cm) eluting with 5% triethylamine in methylene chloride, collecting 100 ml fractions. Fractions number 6 through 12 were combined and concentrated in vacuo (bath temperature less than or equal to 45° C.) to afford an oil. This oil was dissolved in toluene (100 ml) and concentrated to remove residual triethylamine and give 4.54 g of the desired product as an oil.

1. customA 0.5 liter, 4-necked, round-bottom flask, equipped with an overhead stirrer
2. additionthermocouple, addition funnel and a nitrogen inlet/outlet
3. customdried in vacuo at 130° C. for 6 hours
4. additiona 2.5 M solution of n-butyllithium in hexanes (35 ml) was added over about 20 minutes
5. temperaturewhile maintaining the temperature at less than or equal to −60° C
6. temperaturewhile maintaining the temperature at less than or
7. custom68° C
8. additionAfter the addition
9. stirringthe mixture was stirred for an additional 45 minutes
10. temperatureto warm to about 0° C.
11. waitheld at that temperature for 45 minutes
12. customAfter 3 hours reaction time at 0° C.
13. customThe tetrahydrofuran/hexane phase was separated from the lower aqueous phase
14. extractionThe aqueous phase was extracted with methylene chloride (4×100 ml)
15. washwashed with 100 ml of brine
16. dry with materialAfter drying over sodium sulfate and filtration, concentration in vacuo (bath temperature less than or equal to 40° C.)