Benzyl Alcohol → HCID 70117679, compound

HRID 2269699Notes

Reaction equation

HRID 2269699 reaction equation
[ClH:1].[NH2:2][N:3]=[CH:4][NH:5][NH:6][CH2:7][C:8]([OH:10])=[O:9].[CH2:11](O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[ClH:1].[C:12]1([CH2:11][O:9][C:8](=[O:10])[CH2:7][NH:6][NH:5][CH:4]=[N:3][NH2:2])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 3

HCID 244Benzyl AlcoholHCID 313Hydrochloric AcidHCID 71349807[2-(Hydrazinylidenemethyl)hydrazinyl]acetic acid

Product 1

HCID 70117679HCID 70117679, compoundYield 82%

Procedure

HCl (g) was bubbled through a suspension of [2-(aminoiminomethyl)hydrazino]-acetic acid (2.00 g, 15.2 mmol) in benzyl alcohol (30 mL). The reaction was stirred for about an hour until everything was in solution. The crude product was precipitated out by adding Et2O. This material was recrystallized from MeOH/EtOAc to yield [2-(aminoiminomethyl)hydrazino] acetic acid phenylmethyl ester monohydrochloride (3.20 g, 82%) as a white crystalline solid.

Workup

  1. customThe crude product was precipitated out
  2. additionby adding Et2O
  3. customThis material was recrystallized from MeOH/EtOAc

Sources & evidence

ORD record
ord-90f973ed641b40baab57005d8fcef1d2
Source dataset
uspto-grants-2001_12
Patent number
US06329545B1

Reaction notes

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