HCID 18333006, compound → HCID 18332950, compound

HRID 2269749Notes

Reaction equation

HRID 2269749 reaction equation
[CH3:1][N:2]([CH3:27])[C:3]([CH:5]1[CH2:14][C:13]2[C:8](=[CH:9][C:10]([NH:15]C(OCC3C=CC=CC=3)=O)=[CH:11][CH:12]=2)[NH:7][C:6]1=[O:26])=[O:4].[H][H]>CO.C1COCC1.[C].[Pd]>[CH3:1][N:2]([CH3:27])[C:3]([CH:5]1[CH2:14][C:13]2[C:8](=[CH:9][C:10]([NH2:15])=[CH:11][CH:12]=2)[NH:7][C:6]1=[O:26])=[O:4]

Participants

6

Reactant 2

HCID 18333006HCID 18333006, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18332950HCID 18332950, compoundYield 92.2%

Reagents, catalysts & solvents 3

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a suspension of N,N-dimethyl-7-benzyloxycarbonylamino-2-oxo-1,2,3,4-tetrahydro-3-quinolinecarboxamide (820 mg) in methanol (8 ml) and THF (8 ml) was added 10% palladium-carbon (100 mg). The reaction mixture was stirred under one atmospheric pressure of hydrogen at room temperature for 4 hours. The catalyst was removed by filtration and the filtrate was concentrated. The precipitated crystals were washed with combined solution of IPE and THF to obtain the entitled compound (480 mg).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated
  3. washThe precipitated crystals were washed with combined solution of IPE and THF

Sources & evidence

ORD record
ord-0a978dc9f37c4273bb441a3477de6e94
Source dataset
uspto-grants-2001_12
Patent number
US06329389B1

Reaction notes

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