反应详情

Into 250 ml of methanol, 11.3 g of thus obtained 3-(4,5-dimethoxy-2-nitrophenyl)-2-methyl-2-propenoic acid ethyl ester (1) were dissolved. With 45 ml of a 2-N aqueous sodium hydroxide solution being added thereto, the resulting mixture was reacted for 4 hours at 40° C. After the completion of the reaction, 1-N hydrochloric acid was used so as to adjust the pH of the solution at 4, the solution was cooled, and the precipitated crystal was filtered out, whereby 10.1 g of the aimed compound were obtained (yield: 99%).

1. customthe resulting mixture was reacted for 4 hours at 40° C
2. temperaturethe solution was cooled
3. filtrationthe precipitated crystal was filtered out