HCID 18188678, compound → HCID 18188573, compound

HRID 2269796Notes

Reaction equation

HRID 2269796 reaction equation
C(OC([NH:11][C:12]1[CH:30]=[CH:29][C:15]2[C:16]3[C:24]([O:25][CH:26]([F:28])[F:27])=[CH:23][CH:22]=[CH:21][C:17]=3[O:18][CH:19]([OH:20])[C:14]=2[C:13]=1Br)=O)C1C=CC=CC=1>[Pd].CO>[NH2:11][C:12]1[CH:30]=[CH:29][C:15]2[C:16]3[C:24]([O:25][CH:26]([F:28])[F:27])=[CH:23][CH:22]=[CH:21][C:17]=3[O:18][CH:19]([OH:20])[C:14]=2[CH:13]=1

Participants

4

Reactant 1

HCID 18188678HCID 18188678, compound

Product 1

HCID 18188573HCID 18188573, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of Example 27E (0.5 g, 1.04 mmol) and 10% palladium on carbon (50 mg) in methanol (50 mL) was shaken under hydrogen gas (balloon) for 6 hours, filtered through diatomaceous earth (Celite®), and concentrated to provide the desired product. MS (ESI(−)Q1MS) m/z 278 (M−H)−.

Workup

  1. filtrationfiltered through diatomaceous earth (Celite®)
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-a77f8ef0b9d04005a8799dccc7ce5036
Source dataset
uspto-grants-2001_12
Patent number
US06329534B1

Reaction notes

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