Dichloromethane → HCID 69989911, compound

HRID 2269812Notes

Reaction equation

HRID 2269812 reaction equation
[CH2:1]([NH:9][C:10](=[O:31])[CH:11]([NH:23]C(OC(C)(C)C)=O)[C:12]([NH:14][CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:13])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.ClCCl.[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38]>C(Cl)(Cl)(Cl)Cl>[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38].[CH2:15]([NH:14][C:12](=[O:13])[CH:11]([NH2:23])[C:10]([NH:9][CH2:1][CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1)=[O:31])[CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acid2×HCID 18348138HCID 18348138, compound

Product 1

HCID 69989911HCID 69989911, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

Combine N,N′-diphenethyl-2-(t-butoxycarbonylamino)malonamide (0.571 g, 1.35 mmol) and dichloromethane (10 mL). Add trifluoroacetic acid (1.8 mL). After 2.5 hours, evaporate in vacuo to give a residue. Add hexanes and carbon tetrachloride to co-evaporate residual trifluoroacetic acid and evaporate in vacuo to give the title compound (100%).

Workup

  1. customevaporate in vacuo
  2. customto give a residue
  3. customevaporate in vacuo

Sources & evidence

ORD record
ord-dc629a2118a04b33aa723864df14acbd
Source dataset
uspto-grants-2001_12
Patent number
US06329550B1

Reaction notes

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