HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 57217334, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| Reactant | (R)-2-Bromo-3-phenylpropionic acid | HCID 11746403 | — |
| Reactant | HCID 69989911 | HCID 69989911 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 57217334 | HCID 57217334 | 60% |
Reaction Steps
Prepare by the method of Example 1.3 using N,N′-diphenethyl-2-aminomalonamide trifluoroacetic acid salt (0.61 g, 0.600 mmol), (R)-2-bromo-3-phenylpropionic acid (0.137 g, 0.600 mmol), N-methylmorpholine (0.20 mL, 1.8 mmol), 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloric acid salt (0.14 g, 0.72 mmol), and 1-hydroxybenztriazole hydrate (0.097 g, 0.72 mmol) in dichloromethane (10 mL). Purify by chromatography on silica gel eluting with 1/1 ethyl acetate/hexane to give the title compound (60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329550B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-a2d2472ac2b94cf9be5e8bd70831ae5c |
| Source note | uspto-grants-2001_12 |