Trifluoroacetic acid → HCID 69989154, compound

HRID 2269821Notes

Reaction equation

HRID 2269821 reaction equation
[CH2:1]([NH:8][C:9](=[O:29])[CH:10]([NH:21]C(OC(C)(C)C)=O)[C:11]([NH:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33]>ClCCl>[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33].[CH2:14]([NH:13][C:11](=[O:12])[CH:10]([NH2:21])[C:9]([NH:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[O:29])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 18348128N,N'-dibenzyl-2-(t-butoxycarbonylamino)malonamide

Product 1

HCID 69989154HCID 69989154, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Combine N,N′-dibenzyl-2-(t-butoxycarbonylamino)malonamide (0.415 g, 1.04 mmol) and dichloromethane (7 mL). Add trifluoroacetic acid (1.0 mL). After 2.5 hours, evaporate in vacuo dry under high vacuum to give the title compound.

Workup

  1. customevaporate in vacuo
  2. customdry under high vacuum

Sources & evidence

ORD record
ord-1191ca9f1ba24f3d93d0f17fab9eec34
Source dataset
uspto-grants-2001_12
Patent number
US06329550B1

Reaction notes

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