HRID2269882

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15542885

未命名化合物

结构：COc1ccc(CC2(CCS(C)(=O)=O)CCN(Cc3cc(OC)c(OC)c(OC)c3)C2=O)cc1OC

HCID18333553

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CC2(CCN3CCC(O)(c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(Cc3cc(OC)c(OC)c(OC)c3)C2=O)cc1OC

HCID10147165

未命名化合物

PROCEDURE

实验过程

Prepare by the method of Example 6.6.2 using 1-(3,4,5-trimethoxy-benzyl)-3-(3,4-dimethoxy-phenylmethyl)-3-(2-methanesulfonyl-ethyl)-2-oxo-pyrrolidine and 4-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-yl]-4-hydroxy-piperidine to give the title compound: Rf=0.58 (silica gel, 10% methanol/ethyl acetate).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-11ad2bd9aa1f4655922dfa5b16682450
来源数据集: uspto-grants-2001_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06329392B1
来源说明: uspto-grants-2001_12

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:30]=[C:31]([O:35][CH3:36])[C:32]=1[O:33][CH3:34])[CH2:6][N:7]1[CH2:11][CH2:10][C:9]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[C:21]([O:27][CH3:28])[CH:20]=2)([CH2:12][CH2:13]S(C)(=O)=O)[C:8]1=[O:29].[F:37][C:38]1[CH:60]=[CH:59][C:41]([CH2:42][N:43]2[C:47]3[CH:48]=[CH:49][CH:50]=[CH:51][C:46]=3[N:45]=[C:44]2[C:52]2([OH:58])[CH2:57][CH2:56][NH:55][CH2:54][CH2:53]2)=[CH:40][CH:39]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:30]=[C:31]([O:35][CH3:36])[C:32]=1[O:33][CH3:34])[CH2:6][N:7]1[CH2:11][CH2:10][C:9]([CH2:12][CH2:13][N:55]2[CH2:56][CH2:57][C:52]([C:44]3[N:43]([CH2:42][C:41]4[CH:59]=[CH:60][C:38]([F:37])=[CH:39][CH:40]=4)[C:47]4[CH:48]=[CH:49][CH:50]=[CH:51][C:46]=4[N:45]=3)([OH:58])[CH2:53][CH2:54]2)([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[C:21]([O:27][CH3:28])[CH:20]=2)[C:8]1=[O:29]