反应详情

A solution of compound 13 and compound 12 (850 mg, 6.13 mmol) in THF (10 mL) was heated to reflux and allowed to stir overnight. The reaction mixture was allowed to cool and the THF evaporated (in vacuo). The residue was dissolved in ethyl acetate and washed with water. The organic layer was dried over MgSO4 and treated with activated carbon Norit A. The mixture was filtered through Celite 521, and evaporated (in vacuo) and the residue was purified using column chromatography (20% Ethyl acetate/hexanes) to afford compound 10 as a light yellow solid.

1. temperatureto reflux
2. temperatureto cool
3. customthe THF evaporated (in vacuo)
4. dissolutionThe residue was dissolved in ethyl acetate
5. washwashed with water
6. dry with materialThe organic layer was dried over MgSO4
7. additiontreated with activated carbon Norit A
8. filtrationThe mixture was filtered through Celite 521
9. customevaporated (in vacuo)
10. customthe residue was purified