Diphenyl Ether → 3-(3,4-Dimethyl-benzoyl)-6,7-dimethyl-1H-[1,8]naphthyridin-4-one

Participants

Reaction Steps

Experimental conditions analogous to those described for Step 1 of Example 1 were used with 0.50 g (2.01 mmol) 2-(3,4-Dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester, 0.25 g (2.01 mmol) of 5,6-Dimethyl-pyridin-2-ylamine, and 15 mL of diphenyl ether to yield 68.7 mg of 3-(3,4-Dimethyl-benzoyl)-6,7-dimethyl-1H-[1,8]naphthyridin-4-one as a brown solid.

Provenance & Evidence