Diphenyl Ether → 3-(3,4-Dimethyl-benzoyl)-6,7-dimethyl-1H-[1,8]naphthyridin-4-one
Reaction equation
CO[C:3](=[O:18])[C:4]([C:8](=[O:17])[C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[C:11]([CH3:16])[CH:10]=1)=[CH:5]OC.[CH3:19][C:20]1[CH:21]=[CH:22][C:23]([NH2:27])=[N:24][C:25]=1[CH3:26].C1(OC2C=CC=CC=2)C=CC=CC=1>>[CH3:16][C:11]1[CH:10]=[C:9]([CH:14]=[CH:13][C:12]=1[CH3:15])[C:8]([C:4]1[C:3](=[O:18])[C:22]2[C:23](=[N:24][C:25]([CH3:26])=[C:20]([CH3:19])[CH:21]=2)[NH:27][CH:5]=1)=[O:17]Participants
4
Procedure
Experimental conditions analogous to those described for Step 1 of Example 1 were used with 0.50 g (2.01 mmol) 2-(3,4-Dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester, 0.25 g (2.01 mmol) of 5,6-Dimethyl-pyridin-2-ylamine, and 15 mL of diphenyl ether to yield 68.7 mg of 3-(3,4-Dimethyl-benzoyl)-6,7-dimethyl-1H-[1,8]naphthyridin-4-one as a brown solid.
Sources & evidence
- ORD record
- ord-c9b11b81cfaa4f95b17d87973f15c8e1
- Source dataset
- uspto-grants-2009_07
- Patent number
- US07557213B2
Reaction notes
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