Hydrochloric Acid → HCID 69637521, compound

HRID 2270039Notes

Reaction equation

HRID 2270039 reaction equation
[OH:1][CH:2]([CH2:16][NH:17][CH:18]([CH3:20])[CH3:19])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([O:14]C)=[O:13])=[CH:7][CH:6]=1.[ClH:21]>>[ClH:21].[OH:1][CH:2]([CH2:16][NH:17][CH:18]([CH3:20])[CH3:19])[CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:11][C:12]([OH:14])=[O:13])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 12941056HCID 12941056, compound

Product 1

HCID 69637521HCID 69637521, compound

Procedure

A solution of methyl 4-[2-hydroxy-3-[(1-methylethyl)amino]-propoxy]phenylacetate (563 mg, 2.00 mmol) in 6 M hydrochloric acid (15 ml) was heated at 100° C. for 4h. The reaction mixture was concentrated (rotavapor) and the residue was taken up in water and lyophilised. 1H and 13C NMR spectra were in accordance with the strucure and MALDI mass spectrometry gave a M+H at 268 as expected.

Workup

  1. concentrationThe reaction mixture was concentrated (rotavapor)
  2. customgave a M+H at 268

Sources & evidence

ORD record
ord-9c6c176471f84d8a89a06ef799232be1
Source dataset
uspto-grants-2001_12
Patent number
US06331289B1

Reaction notes

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