反应详情

To a solution of 1-hydroxybenzotriazole (722 mg) and 4-[2-(4-pentyloxyphenyl)thiazol-5-yl]benzoic acid (1.64 g) in dichloromethane (33 ml) was added 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride (WSC.HCl) (1.28 g), and stirred for 2 hours at ambient temperature. To the reaction mixture was added dichloromethane (500 ml) to be clear solution, then washed with water (200 ml×2) and brine, and dried over magnesium sulfate. Magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure. The solids were slurried in acetonitrile, and collected by filtration to give 4-[2-(4-pentyloxyphenyl)-thiazol-5-yl]benzoic acid benzotriazol-1-yl ester (1.27 g).

1. washwashed with water (200 ml×2) and brine
2. dry with materialdried over magnesium sulfate
3. filtrationMagnesium sulfate was filtered off
4. customthe filtrate was evaporated under reduced pressure
5. filtrationcollected by filtration