反应详情

To a solution of 2-(4-methoxycarbonylbenzamido)-4′-methoxyacetophenone (4.0 g) in tetrahydrofuran (80 ml) was added phosphorus pentasulfide (3.53 g), and refluxed for 2.5 hours. The reaction mixture was additionally added phosphorus pentasulfide (1.0 g), and refluxed for 1 hour. The reaction mixture was filtered, and the filtrate was cooled, and poured into water (1200 ml), and stirred for 1 hour. The resulting precipitate was collected by filtration. The solids were slurried in acetonitrile, and collected by filtration to give methyl 4-[5-(4-methoxyphenyl)thiazol-2-yl]benzoate (3.26 g).

1. temperaturerefluxed for 2.5 hours
2. temperaturerefluxed for 1 hour
3. filtrationThe reaction mixture was filtered
4. temperaturethe filtrate was cooled
5. additionpoured into water (1200 ml)
6. filtrationThe resulting precipitate was collected by filtration
7. filtrationcollected by filtration