Methyl chloroformate → Benzyl chloroformate

HRID 2270102Notes

Reaction equation

HRID 2270102 reaction equation
ClC1C=NC=C(Cl)C=1N[C:9]([C:11]1[C:20](=O)[C:19]2C(=N[CH:16]=[CH:17][CH:18]=2)N(N2CCN(C)CC2)C=1)=[O:10].[Cl:30][C:31](OC)=[O:32]>>[Cl:30][C:31]([O:10][CH2:9][C:11]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:32]

Participants

3

Reactant 2

HCID 6586Methyl chloroformateHCID 18331335HCID 18331335, compound

Product 1

HCID 10387Benzyl chloroformate

Procedure

The same reaction was carried out as in Example 23, except for using N-(3,5-dichloropyridin-4-yl)-1-(4-methylpiperazin-1-yl)-1,4-dihydro[1,8]naphtyridin-4-one-3-carboxamide, instead of ethyl 1-(1-benzylpiperidin-3-yl)-1,4-dihydro[1,8]naphtyridin-4-one-3-carboxylate and using methyl chloroformate, instead of benzyl chloroformate, to obtain 85 mg (53%) of the above-identified compound as a colorless crystal.

Workup

  1. customThe same reaction

Sources & evidence

ORD record
ord-2f028c4c466240d9af756546681cffc6
Source dataset
uspto-grants-2001_12
Patent number
US06331548B1

Reaction notes

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