HRID2270108

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1032

未命名化合物

结构：Cc1ccccc1NC(=O)Nc1ccc(CN2C(=O)N(CC(=O)NC[C@H](NC(=O)OCc3ccccc3)C(=O)O)C(=O)C2(C)C)cc1

HCID59917102

未命名化合物

PRODUCTS

生成物

结构：Cc1ccccc1NC(=O)Nc1ccc(CN2C(=O)N(CC(=O)NC[C@H](NC(=O)OCc3ccccc3)C(=O)OC(C)C)C(=O)C2(C)C)cc1

HCID59977140

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

The compound was prepared from (S)-2-benzyloxycarbonylamino-3-((4,4-dimethyl-3-(4-(3-(2-methylphenyl)ureido)benzyl)-2,5-dioxoimidazolidin-1-yl)acetylamino)propionic acid and isopropanol as described in Examples 95, 96, 98-102 and 104-116. Batch size: 0.465 mmol of the starting propionic acid. Yield: 233 mg.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2f2341f13e62442082e73353b5a31d23
来源数据集: uspto-grants-2001_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06331552B1
来源说明: uspto-grants-2001_12

反应 SMILES

[CH2:1]([O:8][C:9]([NH:11][C@@H:12]([CH2:16][NH:17][C:18](=[O:47])[CH2:19][N:20]1[C:24](=[O:25])[C:23]([CH3:27])([CH3:26])[N:22]([CH2:28][C:29]2[CH:34]=[CH:33][C:32]([NH:35][C:36]([NH:38][C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=3[CH3:45])=[O:37])=[CH:31][CH:30]=2)[C:21]1=[O:46])[C:13]([OH:15])=[O:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:48](O)(=O)[CH2:49][CH3:50]>C(O)(C)C>[CH2:1]([O:8][C:9]([NH:11][C@@H:12]([CH2:16][NH:17][C:18](=[O:47])[CH2:19][N:20]1[C:24](=[O:25])[C:23]([CH3:27])([CH3:26])[N:22]([CH2:28][C:29]2[CH:30]=[CH:31][C:32]([NH:35][C:36]([NH:38][C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=3[CH3:45])=[O:37])=[CH:33][CH:34]=2)[C:21]1=[O:46])[C:13]([O:15][CH:49]([CH3:50])[CH3:48])=[O:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1