反应详情

1.45 g (38.1 mmol) of lithium aluminum hydride were added in portions with ice-cooling to a suspension of 3.5 g (15.2 mmol) of ethyl (S)-3-amino-3-phenyl-propionate hydrochloride in 150 ml of absolute THF and the mixture was stirred at room temperature for 1 hour. 5 ml of water were then cautiously added dropwise the ice-cooling. The precipitate was filtered off and the filtrate was concentrated in vacuo. The residue was taken up in DCM and the solution was extracted with water. The organic phase was dried over sodium sulfate. After filtration and removal of the solvent in vacuo, 1.84 g of (S)-3-amino-3-phenylpropanol were obtained.

1. temperaturecooling
2. filtrationThe precipitate was filtered off
3. concentrationthe filtrate was concentrated in vacuo
4. extractionthe solution was extracted with water
5. dry with materialThe organic phase was dried over sodium sulfate
6. filtrationAfter filtration and removal of the solvent in vacuo