1-Ethyl-1H-pyrazol-5-amine → HCID 9902007, compound

HRID 2270128Notes

Reaction equation

HRID 2270128 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:15]([OH:17])=O)=[C:7]2[C:11]=1[O:10][C:9]([CH2:12][O:13][CH3:14])=[CH:8]2.[CH2:18]([N:20]1[C:24]([NH2:25])=[CH:23][CH:22]=[N:21]1)[CH3:19]>>[CH2:18]([N:20]1[C:24]([NH:25][C:15]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[C:11]3[O:10][C:9]([CH2:12][O:13][CH3:14])=[CH:8][C:7]=23)=[O:17])=[CH:23][CH:22]=[N:21]1)[CH3:19]

Participants

3

Reactant 2

HCID 3373101-Ethyl-1H-pyrazol-5-amineHCID 18423641HCID 18423641, compound

Product 1

HCID 9902007HCID 9902007, compoundYield 16.7%

Procedure

Starting from 7-methoxy-2-methoxymethylbenzofuran-4-carboxylic acid (0.15 g) and 2-ethyl-2H-pyrazol-3-ylamine (85 mg). Purification by column chromatography on silica eluting with 50% ethyl acetate in heptane increasing to ethyl acetate afforded the title compound as a yellow solid (35 mg).

Workup

  1. customPurification by column chromatography on silica eluting with 50% ethyl acetate in heptane increasing to ethyl acetate

Sources & evidence

ORD record
ord-7270fedb0d0c43cd9fbbe96a0479b1b2
Source dataset
uspto-grants-2001_12
Patent number
US06331556B2

Reaction notes

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