Formamide → 6,7-Dimethoxy-3H-quinazolin-4-one

HRID 2270133Notes

Reaction equation

HRID 2270133 reaction equation
[CH3:1][O:2][C:3]1[C:11]([O:12][CH3:13])=[CH:10][C:6]([C:7](O)=[O:8])=[C:5]([NH2:14])[CH:4]=1.[CH:15]([NH2:17])=O>O>[CH3:13][O:12][C:11]1[CH:10]=[C:6]2[C:5](=[CH:4][C:3]=1[O:2][CH3:1])[N:14]=[CH:15][NH:17][C:7]2=[O:8]

Participants

4

Reactant 2

HCID 713FormamideHCID 797364,5-Dimethoxyanthranilic acid

Product 1

HCID 1354950166,7-Dimethoxy-3H-quinazolin-4-oneYield 12%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

7 g 4,5-dimethoxy 2-amino benzoic acid and 8 ml formamide were heated 2 hours at 170° C. Cold water was added and the solid filtered to give 0.9 g, 12% yield, light-brown solid, mp. 308° C.

Workup

  1. filtrationthe solid filtered
  2. customto give 0.9 g, 12% yield, light-brown solid, mp. 308° C.

Sources & evidence

ORD record
ord-b49b76a3d3d645e68641aa984371a0a5
Source dataset
uspto-grants-2001_12
Patent number
US06331555B1

Reaction notes

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