Sodium → Methyl 4(cyanoethoxycarbonylmethylidenehydrazino)2-[3-(4,6-dimethoxypyrimidin-2-yl)ureidosulfonyl]benzoate

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Reaction Steps

0.7 g (1.25 mmol) of methyl 4-(cyanoethoxycarbonylmethylhydrazino)-2-[3-(4,6-dimethoxypyrimidin-2-yl)ureidosulfonyl]benzoate, sodium salt, are dissolved in 15 ml of water. The few undissolved components are filtered off and the filtrate is acidified to pH 1 using 2N hydrochloric acid. The precipitated solid is filtered off with suction, washed with water and dried. This gives 0.5 g (75% of theory) of methyl 4-(cyanoethoxycarbonyl-methyldenhydrazino)-2-[3-(4,6-dimethoxypyrimidin-2-yl) ureidosulfonyl]benzoate of m.p. 145° C. (decomp.)

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