Sodium → Methyl 4(cyanoethoxycarbonylmethylidenehydrazino)2-[3-(4,6-dimethoxypyrimidin-2-yl)ureidosulfonyl]benzoate

HRID 2270139Notes

Reaction equation

HRID 2270139 reaction equation
[C:1]([CH2:3][CH2:4][O:5][C:6]([CH2:8][NH:9][NH:10][C:11]1[CH:20]=[CH:19][C:14]([C:15]([O:17][CH3:18])=[O:16])=[C:13]([S:21]([NH:24][C:25]([NH:27][C:28]2[N:33]=[C:32]([O:34][CH3:35])[CH:31]=[C:30]([O:36][CH3:37])[N:29]=2)=[O:26])(=[O:23])=[O:22])[CH:12]=1)=[O:7])#[N:2].[Na]>O>[C:1]([CH2:3][CH2:4][O:5][C:6]([CH:8]=[N:9][NH:10][C:11]1[CH:20]=[CH:19][C:14]([C:15]([O:17][CH3:18])=[O:16])=[C:13]([S:21]([NH:24][C:25]([NH:27][C:28]2[N:33]=[C:32]([O:34][CH3:35])[CH:31]=[C:30]([O:36][CH3:37])[N:29]=2)=[O:26])(=[O:23])=[O:22])[CH:12]=1)=[O:7])#[N:2]

Participants

4

Reactant 2

HCID 5360545SodiumHCID 70215059HCID 70215059, compound

Product 1

HCID 70214940Methyl 4(cyanoethoxycarbonylmethylidenehydrazino)2-[3-(4,6-dimethoxypyrimidin-2-yl)ureidosulfonyl]benzoate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.7 g (1.25 mmol) of methyl 4-(cyanoethoxycarbonylmethylhydrazino)-2-[3-(4,6-dimethoxypyrimidin-2-yl)ureidosulfonyl]benzoate, sodium salt, are dissolved in 15 ml of water. The few undissolved components are filtered off and the filtrate is acidified to pH 1 using 2N hydrochloric acid. The precipitated solid is filtered off with suction, washed with water and dried. This gives 0.5 g (75% of theory) of methyl 4-(cyanoethoxycarbonyl-methyldenhydrazino)-2-[3-(4,6-dimethoxypyrimidin-2-yl) ureidosulfonyl]benzoate of m.p. 145° C. (decomp.)

Workup

  1. filtrationThe few undissolved components are filtered off
  2. filtrationThe precipitated solid is filtered off with suction
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-6cf120c13fff4873b4b33e2be84957fc
Source dataset
uspto-grants-2001_12
Patent number
US06331506B1

Reaction notes

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