Triethylamine → HCID 22633010, compound

HRID 2270183Notes

Reaction equation

HRID 2270183 reaction equation
[F:1][C:2]1[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16][C:3]=1[NH:4][C:5]1[CH:13]=[C:12]([F:14])[C:11]([F:15])=[CH:10][C:6]=1[C:7]([OH:9])=O.Cl.[CH2:23]([O:30][NH2:31])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.C(N(CC)CC)C>>[F:1][C:2]1[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16][C:3]=1[NH:4][C:5]1[CH:13]=[C:12]([F:14])[C:11]([F:15])=[CH:10][C:6]=1[C:7]([NH:31][O:30][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:9]

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 102312Benzyloxyamine hydrochlorideHCID 22632910HCID 22632910, compound

Product 1

HCID 22633010HCID 22633010, compoundYield 103.6%

Procedure

Using General Method 2, the reaction of carbonyldiimidazole (2.85 g, 17.6 mmol) 2-(2,4,5-trifluoro-anilino)-4,5-difluorobenzoic acid (Example T, 4.54 g, 14.7 mmol), O-benzylhydroxylamine hydrochloride (2.34 g, 14.7 mmol), and triethylamine (2.45 mL, 17.6 mmol) provided 6.22 g of the crude title compound.

Sources & evidence

ORD record
ord-c29627e991964353b82d4e50016b828b
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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