1,1'-Carbonyldiimidazole → HCID 22632885, compound

HRID 2270184Notes

Reaction equation

HRID 2270184 reaction equation
[C:1](N1C=CN=C1)(N1C=CN=C1)=[O:2].[F:13][C:14]1[CH:39]=[CH:38][C:17]([NH:18][C:19]2[CH:35]=[C:34]([F:36])[C:33]([F:37])=[CH:32][C:20]=2[C:21]([NH:23][O:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[O:22])=[CH:16][CH:15]=1>>[F:13][C:14]1[CH:15]=[CH:16][C:17]([N:18]2[C:19]3[C:20](=[CH:32][C:33]([F:37])=[C:34]([F:36])[CH:35]=3)[C:21](=[O:22])[N:23]([O:24][CH2:25][C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=3)[C:1]2=[O:2])=[CH:38][CH:39]=1

Participants

3

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 22632878HCID 22632878, compound

Product 1

HCID 22632885HCID 22632885, compoundYield 49.1%

Procedure

Using General Method 3, the reaction of carbonyldiimidazole (3.0 g, 18.4 mmol) and crude 2-(4-fluoro-anilino)-N-benzyloxy-4,5-difluoro-benzamide (Example U, 3.43 g, 9.2 mmol) provided 1.8 g of the title compound as a solid, mp 201-202° C.

Sources & evidence

ORD record
ord-312b9d4611c54f09a72b69610603c075
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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