1,1'-Carbonyldiimidazole → HCID 22632893, compound

HRID 2270187Notes

Reaction equation

HRID 2270187 reaction equation
[C:1](N1C=CN=C1)(N1C=CN=C1)=[O:2].[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH:38]=[CH:39][CH:40]=1)[NH:18][C:19]1[CH:35]=[C:34]([F:36])[C:33]([F:37])=[CH:32][C:20]=1[C:21]([NH:23][O:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:22]>>[CH3:13][O:14][C:15]1[CH:16]=[C:17]([N:18]2[C:19]3[C:20](=[CH:32][C:33]([F:37])=[C:34]([F:36])[CH:35]=3)[C:21](=[O:22])[N:23]([O:24][CH2:25][C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=3)[C:1]2=[O:2])[CH:38]=[CH:39][CH:40]=1

Participants

3

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 22632918HCID 22632918, compound

Product 1

HCID 22632893HCID 22632893, compoundYield 18.7%

Procedure

Using General Method 3, the reaction of carbonyldiimidazole (5.5 g, 33.8 mmol) and crude 2-(3-methoxy-anilino)-N-benzyloxy-4,5-difluoro-benzamide (Example X, 6.5 g, 16.9 mmol) provided 1.3 g of the title compound as a solid, mp 157-158° C.

Sources & evidence

ORD record
ord-6ad21ce41201499b85cc7307ca46e09d
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

Loading…