1,1'-Carbonyldiimidazole → HCID 22632946, compound

HRID 2270189Notes

Reaction equation

HRID 2270189 reaction equation
[C:1](N1C=CN=C1)(N1C=CN=C1)=[O:2].[F:13][C:14]1[CH:39]=[C:38]([F:40])[C:37]([F:41])=[CH:36][C:15]=1[NH:16][C:17]1[CH:33]=[C:32]([F:34])[C:31]([F:35])=[CH:30][C:18]=1[C:19]([NH:21][O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:20]>>[F:13][C:14]1[CH:39]=[C:38]([F:40])[C:37]([F:41])=[CH:36][C:15]=1[N:16]1[C:17]2[C:18](=[CH:30][C:31]([F:35])=[C:32]([F:34])[CH:33]=2)[C:19](=[O:20])[N:21]([O:22][CH2:23][C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[C:1]1=[O:2]

Participants

3

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 22633010HCID 22633010, compound

Product 1

HCID 22632946HCID 22632946, compoundYield 5.3%

Procedure

Using General Method 3, the reaction of carbonyldiimidazole (4.9 g, 30.4 mmol) and crude 2-(2,4,5-trifluoro-anilino)-N-benzyloxy-4,5-difluoro-benzamide (Example A-1, 6.22 g, 15.2 mmol) provided 0.35 g of the title compound as a solid.

Sources & evidence

ORD record
ord-00e3ca2c05fe435f8b04ed899bc1304e
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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