Triethylamine → HCID 17899949, compound

HRID 2270207Notes

Reaction equation

HRID 2270207 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:13][CH2:12][NH:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[F:21][C:22]1[CH:23]=[C:24]([N:28]2[C:37]3[C:32](=[CH:33][C:34]([F:39])=[C:35](F)[CH:36]=3)[C:31](=[O:40])[N:30]([O:41][CH2:42][C:43]3[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=3)[C:29]2=[O:49])[CH:25]=[CH:26][CH:27]=1>>[F:21][C:22]1[CH:23]=[C:24]([N:28]2[C:37]3[C:32](=[CH:33][C:34]([F:39])=[C:35]([N:11]4[CH2:12][CH2:13][CH:9]([NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])[CH2:10]4)[CH:36]=3)[C:31](=[O:40])[N:30]([O:41][CH2:42][C:43]3[CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=3)[C:29]2=[O:49])[CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 2757234tert-butyl N-(pyrrolidin-3-yl)carbamateHCID 22632902HCID 22632902, compound

Product 1

HCID 17899949HCID 17899949, compoundYield 85.2%

Procedure

Using General Method 4, the reaction of 3-t-butoxycarbonylamino-pyrrolidine (0.266 g, 1.43 mmol), triethylamine (0.2 mL, 1.43 mmol), and 1-(3-fluorophenyl)-3-benzyloxy-6,7-difluoro-1H-quinazoline-2,4-dione (Example G-1, 0.19 g, 0.48 mmol) provided 0.231 g of the title compound as a solid.

Sources & evidence

ORD record
ord-718ae8f4eb58479da2494ddbf229e425
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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